|
KMID : 0939920150470020215
|
|
대한암학회지
2015 Volume.47 No. 2 p.215 ~ p.220
|
|
|
Five-Year Follow-up Study of Monoclonal Gammopathy of Undetermined Significance in a Korean Elderly Urban Cohort
|
|
:Lee Yun-Gyoo
:Bang Soo-Mee/:Lee Jeong-Ok/:Kim Jin-Won/:Lee Keun-Wook/:Kim Jee-Hyun/:Song Jung-Han/:Kim Tae-Hee/:Kim Ki-Woong/:Lee Jong-Seok
|
|
|
Abstract
|
|
|
Purpose: We previously reported the prevalence of monoclonal gammopathy of undetermined significance (MGUS) to be 3.3% among an elderly Korean urban cohort recruited during 2005-2006. Here, we report a 5-year follow-up study of the previously identified MGUS cohort.
Materials and Methods: The 680 participants from the initial cohort were followed-up for a median of 5 years. Sera were collected between 2010 and 2011. Two-step screening was performed with standard serum electrophoresis followed by immunofixation and determination of the serum concentration of monoclonal-protein (M-protein).
Results: Of the 680 participants (21 with MGUS), 348 (51%) agreed to participate in the follow-up study and 10 were found to have MGUS. Among the 21 MGUS patients initially identified, nine were followed-up, six had persistent M-protein, and one patient had progressed to multiple myeloma (progression rate, 1.0%/yr). The M-protein disappeared in the remaining two individuals. Among the 339 participants without MGUS who were followed-up, four developed an M-protein. There was no significant difference in survival with respect to the presence of MGUS (p=0.66).
Conclusion: The 5-year follow-up data show that the natural clinical course of MGUS in Korea is similar to that in Western countries. MGUS was not associated with an increased risk of death over the 5-year study period.
|
|
|
KEYWORD
|
|
|
Monoclonal gammopathy of undetermined significance, Prevalence, Follow-up studies
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|